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Treatment adherence in psoriatic patients during COVID-19 pandemic: Real-world data from a tertiary hospital in Greece.

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Treatment adherence in psoriatic patients during COVID-19 pandemic: Real-world data from a tertiary hospital in Greece.

J Eur Acad Dermatol Venereol. 2020 Nov;34(11):e673-e675

Authors: Vakirlis E, Bakirtzi K, Papadimitriou I, Vrani F, Sideris N, Lallas A, Ioannides D, Sotiriou E

PMID: 32558015 [PubMed - indexed for MEDLINE]

Категории: MedLine

Catastrophic acute bilateral lower limbs necrosis associated with COVID-19 as a likely consequence of both vasculitis and coagulopathy.

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Catastrophic acute bilateral lower limbs necrosis associated with COVID-19 as a likely consequence of both vasculitis and coagulopathy.

J Eur Acad Dermatol Venereol. 2020 Nov;34(11):e679-e680

Authors: Del Giudice P, Boudoumi D, Le Guen B, Reverte M, Gutnecht J, Lacour JP, Kraemer JP, Motard A, Roa M

PMID: 32557889 [PubMed - indexed for MEDLINE]

Категории: MedLine

Cutaneous involvement during COVID-19 pandemic: an emerging sign of infection.

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Cutaneous involvement during COVID-19 pandemic: an emerging sign of infection.

J Eur Acad Dermatol Venereol. 2020 Nov;34(11):e680-e682

Authors: Annunziata MC, Patrì A, Ruggiero A, Di Guida A, Menicanti C, Greco V, Fabbrocini G

PMID: 32557847 [PubMed - indexed for MEDLINE]

Категории: MedLine

Symmetric chest pressure ulcers, consequence of prone position ventilation in a patient with COVID-19.

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Symmetric chest pressure ulcers, consequence of prone position ventilation in a patient with COVID-19.

J Eur Acad Dermatol Venereol. 2020 Nov;34(11):e672-e673

Authors: Martínez Campayo N, Bugallo Sanz JI, Mosquera Fajardo I

PMID: 32542928 [PubMed - indexed for MEDLINE]

Категории: MedLine

The red half-moon nail sign: a novel manifestation of coronavirus infection.

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The red half-moon nail sign: a novel manifestation of coronavirus infection.

J Eur Acad Dermatol Venereol. 2020 Nov;34(11):e663-e665

Authors: Neri I, Guglielmo A, Virdi A, Gaspari V, Starace M, Piraccini BM

PMID: 32535979 [PubMed - indexed for MEDLINE]

Категории: MedLine

Introductory histopathological findings may shed light on COVID-19 paediatric hyperinflammatory shock syndrome.

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Introductory histopathological findings may shed light on COVID-19 paediatric hyperinflammatory shock syndrome.

J Eur Acad Dermatol Venereol. 2020 Nov;34(11):e665-e667

Authors: Schnapp A, Abulhija H, Maly A, Armoni-Weiss G, Levin Y, Faitatziadou SM, Molho-Pessach V

PMID: 32535977 [PubMed - indexed for MEDLINE]

Категории: MedLine

Occupational skin disease during the COVID-19 pandemic, as captured in a Dermatology staff clinic in the United Kingdom.

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Occupational skin disease during the COVID-19 pandemic, as captured in a Dermatology staff clinic in the United Kingdom.

J Eur Acad Dermatol Venereol. 2020 Nov;34(11):e670-e671

Authors: Hadjieconomou S, Hughes J, Kamath S

PMID: 32535946 [PubMed - indexed for MEDLINE]

Категории: MedLine

SARS-CoV-2, skin lesions and the need of a multidisciplinary approach.

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SARS-CoV-2, skin lesions and the need of a multidisciplinary approach.

J Eur Acad Dermatol Venereol. 2020 Nov;34(11):e659-e662

Authors: Cabrera-Hernández R, Solano-Solares E, Chica-Guzmán V, Fernández-Guarino M, Fernández-Nieto D, Ortega-Quijano D, de-Andrés-Martín A, Moreno C, Carretero-Barrio I, García-Abellás P, González-de-Olano D, de-la-Hoz-Caballer B

PMID: 32535943 [PubMed - indexed for MEDLINE]

Категории: MedLine

COVID-19-related acute genital ulcers.

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COVID-19-related acute genital ulcers.

J Eur Acad Dermatol Venereol. 2020 Nov;34(11):e655-e656

Authors: Falkenhain-López D, Agud-Dios M, Ortiz-Romero PL, Sánchez-Velázquez A

PMID: 32534473 [PubMed - indexed for MEDLINE]

Категории: MedLine

Teledermatology for acne during COVID-19: high patients' satisfaction in spite of the emergency.

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Teledermatology for acne during COVID-19: high patients' satisfaction in spite of the emergency.

J Eur Acad Dermatol Venereol. 2020 Nov;34(11):e662-e663

Authors: Ruggiero A, Megna M, Annunziata MC, Abategiovanni L, Scalvenzi M, Tajani A, Fabbrocini G, Villani A

PMID: 32534472 [PubMed - indexed for MEDLINE]

Категории: MedLine

Cutaneous manifestations of hospitalized coronavirus disease 2019 patients: a report of six cases with clinicopathologic features and viral RNA in situ hybridization.

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Cutaneous manifestations of hospitalized coronavirus disease 2019 patients: a report of six cases with clinicopathologic features and viral RNA in situ hybridization.

J Eur Acad Dermatol Venereol. 2020 Nov;34(11):e656-e659

Authors: Bitar C, Chan MP, Harms PW, Fullen DR, Gudjonsson JE, Eshaq M, Renati S, Nikle AB, Allen A, Hawkins SD, Huerta T, Lowe L, Andea AA

PMID: 32534469 [PubMed - indexed for MEDLINE]

Категории: MedLine

Cutaneous autoimmune diseases during COVID-19 pandemic.

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Cutaneous autoimmune diseases during COVID-19 pandemic.

J Eur Acad Dermatol Venereol. 2020 Nov;34(11):e667-e670

Authors: Günther C, Aschoff R, Beissert S

PMID: 32534461 [PubMed - indexed for MEDLINE]

Категории: MedLine

Acro-ischaemia and COVID-19 infection: clinical and histopathological features.

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Acro-ischaemia and COVID-19 infection: clinical and histopathological features.

J Eur Acad Dermatol Venereol. 2020 Nov;34(11):e653-e754

Authors: Calvão J, Relvas M, Pinho A, Brinca A, Cardoso JC

PMID: 32488910 [PubMed - indexed for MEDLINE]

Категории: MedLine

The Diagnostic-Therapeutic Care Pathway in Psoriasis: Towards ISO 9001:2015 Certification.

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The Diagnostic-Therapeutic Care Pathway in Psoriasis: Towards ISO 9001:2015 Certification.

Medicina (Kaunas). 2020 May 22;56(5):

Authors: Veronese F, Graziola F, Cammarata E, Andreassi M, Mazzoletti V, Taglietti C, Navarra G, Savoia P, Tiberio R

Abstract
Background and objectives: Psoriasis (Pso) is a common skin condition characterized by a strong psychosocial impact, and is nowadays accepted as a systemic immune-mediated inflammatory disease. Diagnostic-Therapeutic Care Pathways (DTCPs) represent a predefined sequence of diagnostic, therapeutic, and assistance activities that integrate the participation of several specialists to obtain, for each patient, the correct diagnosis and thus the most appropriate therapy. A DTCP was validated in our dermatology clinic (AOU Maggiore della Carità, Novara, Italy). The validation process included the detailed elaboration of a protocol of diagnosis, staging of care, therapies, and follow-up of the patient with Pso. The formalization and adaptation of our DTCP resulted in ISO 9001: 2015 certification in May 2019. Materials and methods: This process involved several stages, including analysis of context and the identification of (i) targets, (ii) indicators, and (iii) service providers. The evaluation was based on a cohort of over 200 patients affected by moderate to severe Pso, who were treated and followed-up at our institution from September 2017 to April 2019. Results: The ISO 9001:2015 quality certification process allowed us to identify our weaknesses, i.e., the long waiting times for the first visit and the reduced physician-patient ratio, but also our strengths, such as the commitment to clinical research, effective collaboration with other specialists, the efficient use of technological and human resources, and attention to ensuring patient follow-up. Conclusions: In qualifying for and achieving the ISO Quality Management System (QMS) certification we were heartened to realize that our basic methodology and approach were fit for purpose. The implementation of the ISO QMS helped us to reorganize our priorities by placing the patient at the center of the process and raising awareness that Pso is not just a skin disease.

PMID: 32455972 [PubMed - indexed for MEDLINE]

Категории: MedLine

Purple Fingers and Toes.

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Purple Fingers and Toes.

Mayo Clin Proc. 2020 07;95(7):1313-1314

Authors: Shakshouk H, Lehman JS

PMID: 32444162 [PubMed - indexed for MEDLINE]

Категории: MedLine

Regulatory T cells in skin injury: At the crossroads of tolerance and tissue repair.

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Regulatory T cells in skin injury: At the crossroads of tolerance and tissue repair.

Sci Immunol. 2020 05 01;5(47):

Authors: Boothby IC, Cohen JN, Rosenblum MD

Abstract
Skin injury is a highly inflammatory process that is carefully regulated to mitigate tissue damage and allow for proper barrier repair. Regulatory T cells (Tregs) are crucial coordinators of the immune response to injury in several organs. Here, we review the emerging role of Tregs in facilitating skin repair after injury. We focus on recently discovered interactions between lymphocytes and nonhematopoietic cells during wound healing and discuss how these interactions are regulated both by "classical" suppressive mechanisms of Tregs and by "nonclassical" reparative Treg functions.

PMID: 32358172 [PubMed - indexed for MEDLINE]

Категории: MedLine

Challenges in diagnosis and management of neutropenia upon exposure to immune-checkpoint inhibitors: meta-analysis of a rare immune-related adverse side effect.

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Challenges in diagnosis and management of neutropenia upon exposure to immune-checkpoint inhibitors: meta-analysis of a rare immune-related adverse side effect.

BMC Cancer. 2020 Apr 14;20(1):300

Authors: Boegeholz J, Brueggen CS, Pauli C, Dimitriou F, Haralambieva E, Dummer R, Manz MG, Widmer CC

Abstract
BACKGROUND: Cancer immunotherapy via immune-checkpoint inhibition (ICI) by antibodies against cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and cell death protein 1 (PD-1) have significantly improved the outcome of metastasized melanoma and of a rapidly increasing number of other cancer types. The anti-tumor effect is often accompanied by immune-related adverse events (irAE). Hematological irAE, specifically neutropenia, are rarely observed. However, neutropenia is associated with high morbidity and mortality due to infection complications. Thus, early detection and treatment is crucial.
METHODS: We present the clinical course of two patients with severe neutropenia after ICI therapy and demonstrate the difficulty of the diagnosis when a comedication of metamizole, a well-known analgesic drug used to treat cancer pain, is present. Further, we provide a comprehensive descriptive and statistical analysis of published data on diagnostics, treatment and infection complication in patients with at least grade 4 neutropenia by a systematic database search.
RESULTS: Finally, 34 patients were analyzed, including the two case reports from our cohort. The median onset of neutropenia was 10.5 weeks after first ICI administration (interquartile range: 6 weeks). In 76% (N = 26), a normalization of the neutrophil count was achieved after a median duration of neutropenia of 13 days. In a subsample of 22 patients with detailed data, the infection rate was 13%, proven by positive blood culture in 3 cases, but 68% (N = 15) presented with fever > 38 °C. Treatment regime differed relevantly, but mainly included G-CSF and intravenous corticosteroids. Death was reported in 14 patients (41%), 3 of whom (9%) were associated with hematological irAE but only two directly associated with neutropenia.
CONCLUSION: With an increasing number of cancer patients eligible to ICI therapy, the incidence of severe hematological toxicities may rise substantially over the next years. Clinicians working in the field of cancer immune therapies should be aware of neutropenia as irAE to provide immediate treatment.

PMID: 32290812 [PubMed - indexed for MEDLINE]

Категории: MedLine

Regulatory T cells in skin injury: At the crossroads of tolerance and tissue repair.

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Regulatory T cells in skin injury: At the crossroads of tolerance and tissue repair.

Sci Immunol. 2020 05 01;5(47):

Authors: Boothby IC, Cohen JN, Rosenblum MD

Abstract
Skin injury is a highly inflammatory process that is carefully regulated to mitigate tissue damage and allow for proper barrier repair. Regulatory T cells (Tregs) are crucial coordinators of the immune response to injury in several organs. Here, we review the emerging role of Tregs in facilitating skin repair after injury. We focus on recently discovered interactions between lymphocytes and nonhematopoietic cells during wound healing and discuss how these interactions are regulated both by "classical" suppressive mechanisms of Tregs and by "nonclassical" reparative Treg functions.

PMID: 32358172 [PubMed - in process]

Категории: MedLine

Xanthelasma palpebrarum after hyaluronic acid injection in the lower eyelid: a case report and review of the literature.

Обзоры @ Pubmed - вс., 03/01/2021 - 20:57
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Xanthelasma palpebrarum after hyaluronic acid injection in the lower eyelid: a case report and review of the literature.

J Cosmet Dermatol. 2021 Jan 02;:

Authors: Trein Cunha Simões Pires V, Wender IO, Santos MF, Sartori GL, Vivian A, Dallagnese G

Abstract
Hyaluronic acid filler treatments are a very popular nonsurgical procedure worldwide, most wanted to create a more attractive profile and correct facial aging. Since its usage has expanded, more complications have been seen. We report a case of a 38 years-old white woman who underwent hyaluronic acid filling in the periorbital area and presented twelve months after with two symmetrically yellowish plaques lesions on the lower eyelids, with no edema or nodules. The lesion appeared to be xanthelasma, in a patient with no history of hyperlipidemia. This is probably a new adverse effect related to injectable fillers and physicians need to be aware of this possibility.

PMID: 33387399 [PubMed - as supplied by publisher]

Категории: MedLine

Analyzing the Efficacy of Isotretinoin in Treating Dissecting Cellulitis: A Literature Review and Meta-Analysis.

Обзоры @ Pubmed - вс., 03/01/2021 - 20:57
Related Articles

Analyzing the Efficacy of Isotretinoin in Treating Dissecting Cellulitis: A Literature Review and Meta-Analysis.

Drugs R D. 2021 Jan 02;:

Authors: Guo W, Zhu C, Stevens G, Silverstein D

Abstract
BACKGROUND AND OBJECTIVE: Dissecting cellulitis of the scalp is a primary scarring alopecia. Isotretinoin is commonly referenced in the literature as a treatment for dissecting cellulitis. The objective of this article was to conduct a review and meta-analysis to assess the efficacy of isotretinoin for treating dissecting cellulitis of the scalp.
METHODS: The following databases were searched for articles prior to 23 June, 2019: PubMed, Embase, Cochrane Central, CINAHL, and Web of Science. Multi-patient studies (more than three) that reported on the administration of isotretinoin for dissecting cellulitis were included. A pooled meta-analysis for improvement of disease burden after isotretinoin administration in patients with dissecting cellulitis of the scalp was performed. A fixed-effects model was used.
RESULTS: Five articles were ultimately used for the quantitative meta-analysis. The overall efficacy rate of isotretinoin in treating dissecting cellulitis of the scalp was estimated to be 0.9 with a 95% confidence interval (0.81-0.97). The sensitivity analysis suggested that the overall efficacy is still very high, with a range of 0.83-0.94. Recurrence was seen in 24% (6/25) of patients. Common associated diseases amongst patients with dissecting cellulitis of the scalp were acne conglobata 20% (30/151) and hidradenitis suppurativa 19% (11/72).
CONCLUSIONS: Isotretinoin is an effective treatment for improving symptoms of dissecting cellulitis of the scalp. Disease recurrence is a common finding for those who undergo successful treatment.

PMID: 33387328 [PubMed - as supplied by publisher]

Категории: MedLine
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