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Prevalence of adult female acne in Colombia: A population-based study

Публикации по акне - пт., 14/01/2022 - 14:00

Int J Womens Dermatol. 2021 Jun 21;7(5Part B):727-730. doi: 10.1016/j.ijwd.2021.06.003. eCollection 2021 Dec.

ABSTRACT

BACKGROUND: Acne is a common inflammatory skin disease with adolescents being the most affected by this condition; however, acne also occurs frequently in the adult population. Adult acne is defined as late-onset acne or acne that persists beyond age 25 years. In terms of epidemiologic data, reports of adult female acne prevalence range from 5.5% to 61.5% around the world.

OBJECTIVE: The aim of this study was to estimate the prevalence and trace the trend of adult female acne in Colombia over the last 5 years.

METHODS: Using nationwide data from the General System of Social Security and Health in Colombia through the Sistema Integrado de Información de la Protección Social database and International Classification of Diseases, 10th Revision, diagnostic codes, a cross-sectional study was conducted to estimate the prevalence of adult female acne in outpatients in Colombia from 2015 to 2019.

RESULTS: For the 5-year study period, overall acne prevalence was 2.14 per 1000 population. The highest annual prevalence (2.94 per 1000 population) was in 2019 and the lowest prevalence (1.71 per 1000 population) was in 2015. Prevalence peaked in patients age 25 to 29 years, and decreased to <1 per 1000 population in those age <50 years.

CONCLUSION: This nationwide study of adult female acne in Colombia suggests an increasing trend in prevalence over the last 5 years. We recommend further studies to determine risk factors involved in this condition.

PMID:35028372 | PMC:PMC8714581 | DOI:10.1016/j.ijwd.2021.06.003

Категории: MedLine, Специальные

Negative perceptions and emotional impact of striae gravidarum among pregnant women

Публикации по акне - пт., 14/01/2022 - 14:00

Int J Womens Dermatol. 2021 Nov 3;7(5Part B):685-691. doi: 10.1016/j.ijwd.2021.10.015. eCollection 2021 Dec.

ABSTRACT

BACKGROUND: The impact of striae gravidarum (SG), or stretch marks of pregnancy, on quality of life (QoL) is unclear.

OBJECTIVE: The purpose of this study was to investigate how SG affect QoL in pregnant women.

METHODS: In this cross-sectional survey study of healthy pregnant women who developed SG during their current pregnancy, we asked about the impact of lesions on emotional, psychological, and life-quality facets. Spearman product-moment correlation coefficients were generated to determine the strength of relationships between variables.

RESULTS: We analyzed 116 valid surveys. Participants reported permanency of SG as the top physical concern (n = 87; 75%). With regard to severity, nearly three-quarters of participants rated their lesions as very prominent (n = 24; 21%) or moderate (n = 57; 49%). Among the life-quality facets queried, embarrassment/self-consciousness was the most frequently associated with SG, with over one-third of participants reporting "a lot" (n = 19; 16%) or a "moderate" (n = 26; 22%) amount of embarrassment/self-consciousness related to having SG. Lesion severity significantly correlated with the degree of embarrassment/self-consciousness (r = .543), as well as the impact of SG on other life-quality facets, including overall QoL (r = .428), clothing choice (r = .423), self-image/self-esteem (r = .417), feelings of anxiety/depression (r = .415), and social activities (r = .313; all p ≤ .001). Nearly one-quarter of participants believed that emotional distress related to SG was similar or greater than that caused by other skin problems, such as acne, psoriasis, or eczema.

CONCLUSION: SG can be associated with a host of negative reactions reflecting increased psychological and emotional distress, including embarrassment and decreased QoL. These consequences may compound the emotional stress of pregnancy, potentially warranting psychological support and adjustment strategies.

PMID:35028366 | PMC:PMC8714569 | DOI:10.1016/j.ijwd.2021.10.015

Категории: MedLine, Специальные

Analysis of Trend of Studies on Microneedle Treatment System (MTS)

Публикации по акне - пт., 14/01/2022 - 14:00

J Pharmacopuncture. 2021 Dec 31;24(4):182-190. doi: 10.3831/KPI.2021.24.4.182.

ABSTRACT

OBJECTIVES: The purpose of this study was to analyze the microneedle therapy system (MTS) and its research methods for the past 10 years in Korea.

METHODS: Data on microneedle therapy system were collected using NDSL, KISS, RISS, and OASIS electronic databases from January 2010 to August 2021. "microneedle," "derma stamp," "microneedle therapy system" were used as the keywords. The present study, however, excluded data that were 1) unrelated to the microneedle therapy system, 2) from review/meta/protocol studies, and 3) from overseas studies. Data selected through the primary screening process, animal studies, case reports, and clinical data were included in the analysis. However, information data not related to the microneedle therapy system were excluded from the study.

RESULTS: Among the MTS-related papers published from January 2010 to August 2021, 7 animal research, 2 clinical trials, and 10 case studies were published. Based on the research topics, there were 8 papers on skin improvement and skin diseases, 7 papers on hair growth and hair loss, 3 papers on stability, and 1 paper on peripheral facial paralysis.

CONCLUSION: Most of the studies related to MTS focused on skin, hair, and stability. The effect of MTS on hair growth and skin improvement has been confirmed, and it has been proven to have significant effects on the treatment of acne, acne scars, and hair loss in clinical practice. No serious side effects were observed during the MTS treatment, and the safety assessment confirmed that it was safe for use.

PMID:35028169 | PMC:PMC8716704 | DOI:10.3831/KPI.2021.24.4.182

Категории: MedLine, Специальные

Promising Natural Products in New Drug Design, Development, and Therapy for Skin Disorders: An Overview of Scientific Evidence and Understanding Their Mechanism of Action

Публикации по акне - пт., 14/01/2022 - 14:00

Drug Des Devel Ther. 2022 Jan 6;16:23-66. doi: 10.2147/DDDT.S326332. eCollection 2022.

ABSTRACT

The skin is the largest organ in the human body, composed of the epidermis and the dermis. It provides protection and acts as a barrier against external menaces like allergens, chemicals, systemic toxicity, and infectious organisms. Skin disorders like cancer, dermatitis, psoriasis, wounds, skin aging, acne, and skin infection occur frequently and can impact human life. According to a growing body of evidence, several studies have reported that natural products have the potential for treating skin disorders. Building on this information, this review provides brief information about the action of the most important in vitro and in vivo research on the use of ten selected natural products in inflammatory, neoplastic, and infectious skin disorders and their mechanisms that have been reported to date. The related studies and articles were searched from several databases, including PubMed, Google, Google Scholar, and ScienceDirect. Ten natural products that have been reported widely on skin disorders were reviewed in this study, with most showing anti-inflammatory, antioxidant, anti-microbial, and anti-cancer effects as the main therapeutic actions. Overall, most of the natural products reported in this review can reduce and suppress inflammatory markers, like tumor necrosis factor-alpha (TNF-α), scavenge reactive oxygen species (ROS), induce cancer cell death through apoptosis, and prevent bacteria, fungal, and virus infections indicating their potentials. This review also highlighted the challenges and opportunities of natural products in transdermal/topical delivery systems and their safety considerations for skin disorders. Our findings indicated that natural products might be a low-cost, well-tolerated, and safe treatment for skin diseases. However, a larger number of clinical trials are required to validate these findings. Natural products in combination with modern drugs, as well as the development of novel delivery mechanisms, represent a very promising area for future drug discovery of these natural leads against skin disorders.

PMID:35027818 | PMC:PMC8749048 | DOI:10.2147/DDDT.S326332

Категории: MedLine, Специальные

A Fallen-snow-like pattern of hair in trichoteiromania

J Eur Acad Dermatol Venereol. 2022 Jan 14. doi: 10.1111/jdv.17927. Online ahead of print.

NO ABSTRACT

PMID:35030275 | DOI:10.1111/jdv.17927

Категории: Специальные

Cutaneous leishmaniasis over a tattoo mimicking keratoacanthoma in Southern Europe

J Eur Acad Dermatol Venereol. 2022 Jan 14. doi: 10.1111/jdv.17930. Online ahead of print.

NO ABSTRACT

PMID:35030273 | DOI:10.1111/jdv.17930

Категории: Специальные

Benign skin neoplasms in children

Обзоры @ Pubmed - пт., 14/01/2022 - 14:00

Hautarzt. 2022 Jan 14. doi: 10.1007/s00105-021-04935-w. Online ahead of print.

ABSTRACT

There are many different types of skin neoplasms in children and most are benign. Dermatologists should be able to differentiate between the various types of benign skin neoplasms and be able to recommend optimal treatment to concerned patients. Surgical removal of benign skin neoplasms is often the only treatment option. The aim of this paper is to provide a general overview of epidermal lesions (e.g., inflammatory linear verrucous epidermal nevus [ILVEN], nevus sebaceous), tumors of the epidermal appendages (e.g. pilomatrixoma), cutaneous neoplasms (e.g. angiofibroma), fibromatoses (e.g., knuckle pads), tumors comprised of fat, muscle, or bone tissue (e.g., osteoma cutis, subungual exostosis), epidermal cysts and pseudocysts, and pathologic fibrosis reactions after dermal injury (keloid). Scientific data are scarce and only in the last decade has it been possible to perform histopathological examinations and genetic studies together with detailed phenotyping to gain new understanding of the pathogenetic mechanisms.

PMID:35029698 | DOI:10.1007/s00105-021-04935-w

Категории: MedLine

Occupational Contact Dermatitis in Dental Personnel: A Retrospective Analysis of the North American Contact Dermatitis Group Data, 2001 to 2018

Обзоры @ Pubmed - пт., 14/01/2022 - 14:00

Dermatitis. 2022 Jan-Feb 01;33(1):80-90. doi: 10.1097/DER.0000000000000847.

ABSTRACT

BACKGROUND: Dental personnel are at risk of developing occupational contact dermatitis.

OBJECTIVES: The aims of the study were to determine prevalence of occupational contact dermatitis in dental personnel referred for patch testing and to characterize relevant allergens and sources.

METHODS: The study used a retrospective, cross-sectional analysis of the North American Contact Dermatitis Group (NACDG) data, 2001-2018.

RESULTS: Of 41,109 patients, 585 (1.4%) were dental personnel. Dental personnel were significantly more likely than nondental personnel to be female (75.7% vs 67.4%, P < 0.0001), have occupationally related dermatitis (35.7% vs 11.5%, P < 0.0001), and/or have primary hand involvement (48.6% vs 22.5%, P < 0.0001). More than one quarter of dental personnel (62/585, 27.7%) had 1 or more occupationally related allergic patch test reaction(s). There were 249 occupationally related reactions to NACDG screening allergens, most commonly glutaraldehyde (18.1%), thiuram mix (16.1%), and carba mix (14.1%). The most common sources of NACDG screening allergens were gloves (30.7%), dental materials (26.6%), and sterilizing solutions (13.1%). Seventy-three dental personnel (12.5%) had 1 or more positive patch test reactions to occupationally related allergen(s)/substances not on the screening series. Occupationally related irritant contact dermatitis was identified in 22.2% (n = 130) of dental personnel, most commonly to nonskin soaps/detergents/disinfectants (32.0%).

CONCLUSIONS: Occupational contact dermatitis is common in dental personnel referred for patch testing. Comprehensive testing beyond screening series is important in these patients.

PMID:35029351 | DOI:10.1097/DER.0000000000000847

Категории: MedLine

Shoe Allergens: A Retrospective Analysis of Cross-sectional Data From the North American Contact Dermatitis Group, 2005-2018

Обзоры @ Pubmed - пт., 14/01/2022 - 14:00

Dermatitis. 2022 Jan-Feb 01;33(1):62-69. doi: 10.1097/DER.0000000000000750.

ABSTRACT

BACKGROUND: Shoe contact allergy can be difficult to diagnose and manage.

OBJECTIVE: The aim of the study was to characterize demographics, clinical characteristics, patch test results, and occupational data for the North American Contact Dermatitis Group patients with shoe contact allergy.

METHODS: This is a retrospective study of 33,661 patients, patch tested from 2005 to 2018, with a shoe source, foot as 1 of 3 sites of dermatitis, and final primary diagnosis of allergic contact dermatitis.

RESULTS: Three hundred fifty-two patients met the inclusion criteria. They were more likely to be male (odds ratio = 3.36, confidence interval = 2.71-4.17) and less likely to be older than 40 years (odds ratio = 0.49, confidence interval = 0.40-0.61) compared with others with positive patch test reactions. The most common relevant North American Contact Dermatitis Group screening allergens were potassium dichromate (29.8%), p-tert-butylphenol formaldehyde resin (20.1%), thiuram mix (13.3%), mixed dialkyl thioureas (12.6%), and carba mix (12%). A total of 29.8% (105/352) had positive patch test reactions to supplemental allergens, and 12.2% (43/352) only had reactions to supplemental allergens.

CONCLUSIONS: Shoe contact allergy was more common in younger and male patients. Potassium dichromate and p-tert-butylphenol formaldehyde resin were the top shoe allergens. Testing supplemental allergens, personal care products, and shoe components should be part of a comprehensive evaluation of suspected shoe contact allergy.

PMID:35029350 | DOI:10.1097/DER.0000000000000750

Категории: MedLine

Characterization of Residual Facial Dermatitis during Dupilumab Therapy: A Retrospective Chart Review to Delineate the Potential Role of Expanded Series Patch Testing

Обзоры @ Pubmed - пт., 14/01/2022 - 14:00

Dermatitis. 2022 Jan-Feb 01;33(1):51-61. doi: 10.1097/DER.0000000000000801.

ABSTRACT

OBJECTIVE: We sought to determine the incidence of RFDD in patients receiving dupilumab and the rate of resolution of RFDD after expanded series patch testing (ESPT) and allergen avoidance.

METHODS: This is a retrospective chart review of 80 patients with atopic dermatitis who were evaluated for RFDD after treatment with dupilumab. Expanded series patch testing findings and response to allergen avoidance were assessed in the subset of patients with RFDD who subsequently underwent ESPT while continuing to receive dupilumab.

RESULTS: Forty-nine patients (61.3%) experienced facial dermatitis before initiating dupilumab. Thirty-five patients (43.8%) experienced RFDD after starting dupilumab. Of the 14 patients with RFDD who received ESPT, 92.9% had 1 or more relevant positive patch test results, with 50% of such patients being mostly to completely clear of facial dermatitis after allergen avoidance. Importantly, 50.6% of the positive reactions to allergens were not included on the North American Contact Dermatitis Group Core 80.

CONCLUSIONS: Many patients with RFDD benefit from patch testing and subsequent allergen avoidance. Expanded series patch testing should be offered to patients who experience RFDD after beginning dupilumab therapy to ensure that such patients have eliminated any exogenous component of their dermatitis, such as concomitant allergic contact dermatitis.

PMID:35029349 | DOI:10.1097/DER.0000000000000801

Категории: MedLine

Epithelial Barrier: Protector and Trigger of Allergic Disorders

Обзоры @ Pubmed - пт., 14/01/2022 - 14:00

J Investig Allergol Clin Immunol. 2022 Jan 12:0. doi: 10.18176/jiaci.0779. Online ahead of print.

ABSTRACT

The epithelial barrier has been classically considered as only the first line of defense against irritants, pathogens, and allergens, but it is now known that it also plays an essential role in the immunological response against exogenous agents. In fact, recent reports postulate the epithelial barrier hypothesis as a possible explanation for the increasing incidence and severity of allergic diseases. The epithelial barrier preserves the isolation of the inner tissues from potential external threats. Moreover, a coordinated interaction between epithelial and immune cells ensures the unique immune response taking place in mucosal tissues and that is has been reported to be dysregulated in allergic diseases. Herein, we and others have demonstrated that in severe allergic phenotypes, the epithelial barrier experiments several histological modifications and increased in immune cells infiltration, leading to its dysfunction. This is common in atopic dermatitis, asthma, and/or food allergy. However, the precise role of the epithelial barrier in the mucosal biology during allergic diseases progression is not well understood yet. In this review, we aim to compile recent knowledge regarding the histological structure and immunological function of the epithelial barrier and to shed light on the role of this compartment in the onset, and progression of allergic diseases.

PMID:35029152 | DOI:10.18176/jiaci.0779

Категории: MedLine

Biologic and targeted therapeutics in Vitiligo

Обзоры @ Pubmed - пт., 14/01/2022 - 14:00

J Cosmet Dermatol. 2022 Jan 13. doi: 10.1111/jocd.14770. Online ahead of print.

ABSTRACT

Vitiligo is a long standing progressive autoimmune disease with depigmented macules/ patches with a significant psychological morbidity to the patients. From being one of the most poorly understood diseases in the past, there has been a rampant advance in determining the molecular and genetic factors influencing the disease process. More light has been shed on the complex intracellular environment and interplay between the innate and adaptive immunity. Numerous cytokines and signalling pathways have been associated with disease pathogenesis in recent past. However, most conventional treatment modalities are restricted to generalised nonspecific immunosuppressants like topical and oral corticosteroids, calcineurin inhibitors, phototherapy and surgical modalities. There have been reports and studies on the usage of biologicals in treating vitiligo. JAK inhibitors have shown good efficacy in vitiligo, however, it lacks substantial evidence in the form of randomised control trials. Similarly, the use of targeted therapeutics in treating vitiligo is substantiated by limited evidence and requires more randomised trials for further evidence. This article aims at a comprehensive review of all the biologicals and newer targeted therapeutics tried in vitiligo and their efficacy with an insight into the potential complications arising as a result of the therapy.

PMID:35029034 | DOI:10.1111/jocd.14770

Категории: MedLine

Cutaneous mastocytosis in childhood

Обзоры @ Pubmed - пт., 14/01/2022 - 14:00

Allergol Select. 2022 Jan 5;6:1-10. doi: 10.5414/ALX02304E. eCollection 2022.

ABSTRACT

Mastocytoses are characterized by clonal proliferation of mast cells in various tissues. In childhood, cutaneous mastocytosis (CM) occurs almost exclusively. It is confined to the skin, and has a good prognosis. The most common form is the maculopapular cutaneous mastocytosis (MPCM), formerly called urticaria pigmentosa. A distinction is made between a monomorphic variant of MPCM with multiple small, roundish maculopapular skin lesions and the - more common - polymorphic variant with larger lesions of variable size. One quarter of CM diagnosed in childhood are mastocytomas, which often occur solitary or at multiple sites. The diffuse variant of CM (DCM), which affects 5% of children with CM, should be distinguished from these forms. Systemic mastocytoses (SM) with mast cell infiltrates in the bone marrow or other extracutaneous tissues, such as the gastrointestinal tract, occur predominantly in adults. The diagnosis of CM is usually made clinically: Manifestation in infancy, typical morphology and distribution, pathognomonic Darier sign. Basal serum tryptase is determined if DCM or systemic mastocytosis are to be diagnosed. Children with mastocytosis should be managed in a specialized outpatient clinic. For affected families, detailed information about the clinical picture including prognosis assessment is essential. Mast cell mediated symptoms are controlled by oral non-sedating antihistamines if needed.

PMID:35028497 | PMC:PMC8750954 | DOI:10.5414/ALX02304E

Категории: MedLine

Dermatology residency research policies: A 2021 national survey

Обзоры @ Pubmed - пт., 14/01/2022 - 14:00

Int J Womens Dermatol. 2021 May 24;7(5Part B):787-792. doi: 10.1016/j.ijwd.2021.05.003. eCollection 2021 Dec.

ABSTRACT

BACKGROUND: In this follow-up study to previous work, the authors survey the availability of key measures and resources pertaining to residency research in U.S. Accreditation Council for Graduate Medical Education-accredited dermatology residency programs, including potential policy changes following the COVID-19 pandemic.

OBJECTIVE: The chief objective of this survey was to evaluate and compare dermatology programs' resident research requirements and guidelines.

METHODS: This cross-sectional study employed a 13-item survey administered online in early 2021 to assess the degree to which dermatology residency programs require and support their new physician graduates in scholarly research endeavors.

RESULTS: A total of 32 program directors representing 30 dermatology residency programs (30 of 138 accredited programs contacted [22%]) responded to the survey. Almost all programs described quality improvement project requirements for residents and were able to provide funding for resident conference participation. Most programs also reported resident publication requirements and the availability of research electives. However, the vast majority did not have required research rotations or a formal mentorship program. The COVID-19 pandemic did not have a substantial impact on residency research requirements.

CONCLUSION: Our survey provides objective data about the current dermatology resident research requirements across the United States. These findings may prove valuable to prospective applicants, residency programs, and accrediting agencies in improving, advancing, and structuring dermatology residency guidelines and resources with the aim of encouraging new physician trainees to pursue research.

PMID:35028383 | PMC:PMC8714577 | DOI:10.1016/j.ijwd.2021.05.003

Категории: MedLine

Art of prevention: The importance of dermatologic care when using aromatase inhibitors

Обзоры @ Pubmed - пт., 14/01/2022 - 14:00

Int J Womens Dermatol. 2021 Jul 17;7(5Part B):769-773. doi: 10.1016/j.ijwd.2021.07.002. eCollection 2021 Dec.

ABSTRACT

As of January 2021, there are more than 3.8 million women in the United States with a history of breast cancer. The current standard of care for breast cancer involves surgical resection, radiation therapy, adjuvant endocrine therapy, and/or adjuvant chemotherapy. Aromatase inhibitors (AIs) are the gold standard for endocrine therapy in postmenopausal women. Dermatologic adverse events (dAEs) associated with AIs are rare but have been reported in the literature. Commonly reported dAEs include unspecified rash, pruritus, alopecia, vulvovaginal atrophy, vasculitis, and autoimmune/connective tissue disorders. Appropriate preventative strategies and careful management considerations have the potential to optimize the comprehensive care of patients with cancer and improve quality of life. Furthermore, prevention of dAEs can lead to a reduction in cancer treatment interruptions and discontinuations. Herein, we characterize dAEs of AIs and discuss preventative management to reduce the incidence of AI therapy interruption.

PMID:35028380 | PMC:PMC8714559 | DOI:10.1016/j.ijwd.2021.07.002

Категории: MedLine

Plasma cell vulvitis: A systematic review

Обзоры @ Pubmed - пт., 14/01/2022 - 14:00

Int J Womens Dermatol. 2021 May 4;7(5Part B):756-762. doi: 10.1016/j.ijwd.2021.04.005. eCollection 2021 Dec.

ABSTRACT

BACKGROUND: Plasma cell vulvitis (PCV) is an inflammatory vulvar dermatosis that is not well characterized. Diagnosis is often delayed, and the condition can be refractory to treatment. To date, there are no systematic reviews on this topic.

OBJECTIVE: This study aimed to provide a systematic review of PCV, including epidemiologic, clinical, and histopathologic findings, as well as associated comorbidities and treatment options.

METHODS: A primary literature search was conducted using the PubMed, Ovid Medline, Cochrane, and CINAHL databases.

RESULTS: Fifty-three publications with 196 patients (mean age: 55.3 ± 14.5 years) were included. The majority of studies were case reports and case series. Common symptoms included burning/stinging (52%), dyspareunia (44%), and pruritus (41%). Common findings included erythema (84%), glistening/shiny appearance (29%), well-demarcated lesions (25%), and erosions (22%). Common anatomic sites were the labia minora (45%), introitus (31%), and periurethral (19%). Fifty-three percent of patients had a solitary lesion. Common histologic findings were a predominant plasma cell infiltrate (88%), presence of other inflammatory cells (55%), hemosiderin/siderophages (46%), and epidermal atrophy (43%). Topical corticosteroids (64%) and tacrolimus ointment (13%) were the most frequent treatment modalities. In most reports, previous treatments were tried, and there was a diagnostic delay.

CONCLUSION: PCV is likely underrecognized and should be considered in patients with erythema of the mucous and modified mucous membranes, symptoms of burning or stinging, and a predominant plasma cell infiltrate on histopathology. First-line therapy should begin with high-potency topical corticosteroids, with the most evidence for clobetasol 0.05% or tacrolimus 0.1% ointment. Prospective studies are needed to further characterize this condition and to develop treatment guidelines.

PMID:35028377 | PMC:PMC8714578 | DOI:10.1016/j.ijwd.2021.04.005

Категории: MedLine

Hormone therapy and melanoma in women

Обзоры @ Pubmed - пт., 14/01/2022 - 14:00

Int J Womens Dermatol. 2021 Jun 25;7(5Part B):692-696. doi: 10.1016/j.ijwd.2021.06.005. eCollection 2021 Dec.

ABSTRACT

Although primary cutaneous melanoma accounts for approximately 3% of all malignant skin tumors, it has the greatest contribution to skin cancer-related death. Sex-specific differences in melanoma tumor behavior have been described, and melanoma pathogenesis may be hormonally mediated. This review aims to summarize the literature to date regarding the effects of hormone therapy on melanoma in women. Women's exogenous hormone use has changed dramatically over the past few decades. Thus, we focus on studies investigating the associations between oral contraception, fertility treatments, menopausal hormone therapy (MHT), and melanoma. Across hormone therapy types, there does not appear to be a well-established association between exogenous female hormones and melanoma incidence. However, MHT practices and formulations vary significantly across countries. Although MHT does not appear to increase melanoma risk in studies from the United States, conflicting results have been observed in Europe. Unopposed estrogen MHT formulations require further investigation to determine a clear pattern between hormone use and the development of melanoma.

PMID:35028367 | PMC:PMC8714603 | DOI:10.1016/j.ijwd.2021.06.005

Категории: MedLine

Identification of skin signs in human-trafficking survivors

Обзоры @ Pubmed - пт., 14/01/2022 - 14:00

Int J Womens Dermatol. 2021 Oct 2;7(5Part B):677-682. doi: 10.1016/j.ijwd.2021.09.011. eCollection 2021 Dec.

ABSTRACT

Human-trafficking survivors suffer significant physical, mental, and social health consequences, prompting them to seek health care services. Although there is research regarding identification protocols for human-trafficking victims, there is no framework outlining the dermatologic patterns of survivors of human trafficking. We sought to identify the dermatologic signs reported in human-trafficking victims to create a framework for dermatologists and the broader medical community to appropriately screen patients at risk. After screening 577 pertinent records in the PubMed and Google Scholar databases for information about the physical signs of human trafficking in health care, 10 final studies were selected. Significant findings of rashes and brandings, such as tattoos, were more likely in sex-trafficked patients, whereas burns, injuries, and deep cuts were more likely to be found in labor-trafficked patients. This review outlines important identification guidelines that dermatologists and the broader medical community can use to recognize victims and take appropriate action while also raising awareness of human trafficking as an emerging public health issue.

PMID:35028364 | PMC:PMC8714580 | DOI:10.1016/j.ijwd.2021.09.011

Категории: MedLine

Clinical considerations in the management of hidradenitis suppurativa in women

Обзоры @ Pubmed - пт., 14/01/2022 - 14:00

Int J Womens Dermatol. 2021 Oct 29;7(5Part B):664-671. doi: 10.1016/j.ijwd.2021.10.012. eCollection 2021 Dec.

ABSTRACT

Hidradenitis suppurativa (HS) is a chronic, inflammatory disease of the skin with a predilection for women. The role of sex hormones, including estrogen and progesterone, is incompletely understood, but alterations in hormone levels may play a role in disease activity for many patients. Specific clinical considerations should be made for women with HS, particularly in the setting of pregnancy, childbirth, breastfeeding, and menopause. Current knowledge gaps regarding HS include the cumulative impact of disease across an individual's lifespan, as well as the mechanistic role of sex hormones in the disease. An improved understanding of the pathophysiologic role of hormones in HS would optimize our ability to use targeted therapies for hormonally driven disease. Psychological and psychosexual support for women with HS is an important facet of any holistic management strategy for the disease. This article integrates up-to-date pathogenic and mechanistic insights with evidence-based clinical management to optimize care for women with HS.

PMID:35028361 | PMC:PMC8714605 | DOI:10.1016/j.ijwd.2021.10.012

Категории: MedLine

The threat of mosquito-borne arboviral disease in Spain: A bibliographic review

Обзоры @ Pubmed - пт., 14/01/2022 - 14:00

Med Clin (Barc). 2022 Jan 10:S0025-7753(21)00668-0. doi: 10.1016/j.medcli.2021.10.014. Online ahead of print.

ABSTRACT

Over the last two decades there has been an increase in outbreaks of arboviral diseases, being Spain at high risk for disease emergence. This paper reviews the current evidence regarding the transmissibility, disease epidemiology, control strategies and mosquito-borne disease drivers and maintaining factors in Spain. There is risk of autochthonous cases and outbreaks in Spain due to recent transmission occurrence. Recently, there has been an expansion of Aedes Albopticus, a vector for Dengue, Zika and Chikungunya; and Cullex spp., vector for West Nile Virus, already endemic in Spain. Their establishment has been facilitated by climate and environmental drivers. If climate change projections are to be met, an increase in disease transmission is to be expected, as well as the re-establishment of other vectors such as Aedes Aegypti. Our review supports the need to understand the threat of these emerging diseases and implement preventive strategies in order to minimise their impact.

PMID:35027150 | DOI:10.1016/j.medcli.2021.10.014

Категории: MedLine
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